A SECRET WEAPON FOR PKRRATING

The activated enzyme then phosphorylates its main substrate, the translational initiation check here element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to a conserved loved ones of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to distinctive stimuli12, triggering the buil